2QX1
Crystal structure of the complex between mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FABH) and decyl-COA disulfide
Summary for 2QX1
Entry DOI | 10.2210/pdb2qx1/pdb |
Related | 1HNJ 1HNK 1HZP 1U6E 1U6S |
Descriptor | Beta-ketoacyl-ACP synthase III, COENZYME A, DECANE-1-THIOL, ... (4 entities in total) |
Functional Keywords | fatty acid biosynthesis, myobacterium tuberculosis, structural basis for substrate specificity, enzyme inhibitor complex, mechanism based inhibitor, acyltransferase, lipid synthesis, multifunctional enzyme, transferase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 70923.01 |
Authors | Sachdeva, S.,Musayev, F.,Alhamadsheh, M.,Scarsdale, J.N.,Wright, H.T.,Reynolds, K.A. (deposition date: 2007-08-10, release date: 2008-03-18, Last modification date: 2023-08-30) |
Primary citation | Sachdeva, S.,Musayev, F.,Alhamadsheh, M.M.,Neel Scarsdale, J.,Tonie Wright, H.,Reynolds, K.A. Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates Bioorg.Chem., 36:85-90, 2008 Cited by PubMed: 18096200DOI: 10.1016/j.bioorg.2007.11.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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