2QT7

Crystallographic structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2 at 1.30 Angstroms

Summary for 2QT7

Entry DOI	10.2210/pdb2qt7/pdb
Descriptor	Receptor-type tyrosine-protein phosphatase-like N, CALCIUM ION (3 entities in total)
Functional Keywords	ia-2, ica-512, protein-tyrosine phosphatase, transmembrane protein, diabetes, autoimmunity, proteolysis, glycoprotein, receptor, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane ; Single-pass type I membrane protein . ICA512-transmembrane fragment: Cytoplasmic vesicle, secretory vesicle membrane . ICA512-cleaved cytosolic fragment: Nucleus : Q16849
Total number of polymer chains	2
Total formula weight	19796.45
Authors	Primo, M.E.,Klinke, S.,Sica, M.P.,Goldbaum, F.A.,Jakoncic, J.,Poskus, E.,Ermacora, M.R. (deposition date: 2007-08-01, release date: 2007-12-11, Last modification date: 2024-02-21)
Primary citation	Primo, M.E.,Klinke, S.,Sica, M.P.,Goldbaum, F.A.,Jakoncic, J.,Poskus, E.,Ermacora, M.R. Structure of the Mature Ectodomain of the Human Receptor-type Protein-tyrosine Phosphatase IA-2 J.Biol.Chem., 283:4674-4681, 2008 Cited by PubMed: 18048354 DOI: 10.1074/jbc.M708144200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation