2QRG

Glycogen Phosphorylase b in complex with (1R)-3'-(4-methoxyphenyl)-spiro[1,5-anhydro-D-glucitol-1,5'-isoxazoline]

Summary for 2QRG

• Entry DOI: 10.2210/pdb2qrg/pdb
• Related: 2QRH
• Descriptor: Glycogen phosphorylase, muscle form, (5R,7R,8S,9S,10R)-7-(HYDROXYMETHYL)-3-(4-METHOXYPHENYL)-1,6-DIOXA-2-AZASPIRO[4.5]DEC-2-ENE-8,9,10-TRIOL (3 entities in total)
• Functional Keywords: glycogenolysis, type 2 diabetes, acetylation, allosteric enzyme, carbohydrate metabolism, glycogen metabolism, glycosyltransferase, nucleotide-binding, phosphorylation, pyridoxal phosphate, transferase
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 97844.63

Authors

Kizilis, G.,Alexacou, K.-M.,Chrysina, E.D.,Zographos, S.E.,Leonidas, D.D.,Oikonomakos, N.G. (deposition date: 2007-07-28, release date: 2008-08-05, Last modification date: 2023-11-15)

• Primary citation: Benltifa, M.,Hayes, J.M.,Vidal, S.,Gueyrard, D.,Goekjian, P.G.,Praly, J.P.,Kizilis, G.,Tiraidis, C.,Alexacou, K.M.,Chrysina, E.D.,Zographos, S.E.,Leonidas, D.D.,Archontis, G.,Oikonomakos, N.G.; Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.; Bioorg.Med.Chem., 17:7368-7380, 2009; PubMed: 19781947; DOI: 10.1016/j.bmc.2009.08.060

Experimental method

X-RAY DIFFRACTION (1.85 Å)