2QQH
Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense
Summary for 2QQH
Entry DOI | 10.2210/pdb2qqh/pdb |
Descriptor | Complement component C8 alpha chain, SULFATE ION, NICKEL (II) ION, ... (4 entities in total) |
Functional Keywords | macpf, membrane perforation, cleavage on pair of basic residues, complement alternate pathway, complement pathway, cytolysis, egf-like domain, glycoprotein, immune response, innate immunity, membrane attack complex, polymorphism, secreted, immune system, membrane protein |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P07357 |
Total number of polymer chains | 1 |
Total formula weight | 37890.10 |
Authors | Hadders, M.A.,Gros, P. (deposition date: 2007-07-26, release date: 2007-09-25, Last modification date: 2021-10-20) |
Primary citation | Hadders, M.A.,Beringer, D.X.,Gros, P. Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense. Science, 317:1552-1554, 2007 Cited by PubMed: 17872444DOI: 10.1126/science.1147103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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