2QOE

Human Dipeptidyl Peptidase IV in complex with a Triazolopiperazine-based beta amino acid Inhibitor

Summary for 2QOE

• Entry DOI: 10.2210/pdb2qoe/pdb
• Descriptor: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: alpha/beta inhibitors, beta-propeller, dimer, diabetes, aminopeptidase, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 174523.41

Authors

Scapin, G. (deposition date: 2007-07-20, release date: 2007-11-06, Last modification date: 2024-10-09)

Primary citation

Kowalchick, J.E.,Leiting, B.,Pryor, K.D.,Marsilio, F.,Wu, J.K.,He, H.,Lyons, K.A.,Eiermann, G.J.,Petrov, A.,Scapin, G.,Patel, R.A.,Thornberry, N.A.,Weber, A.E.,Kim, D.
Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.
Bioorg.Med.Chem.Lett., 17:5934-5939, 2007

PubMed Abstract: Various beta-amino amides containing triazolopiperazine heterocycles have been prepared and evaluated as potent, selective, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. These compounds display excellent oral bioavailability and good overall pharmacokinetic profiles in preclinical species. Moreover, in vivo efficacy in an oral glucose tolerance test in lean mice is demonstrated.

PubMed: 17827003
DOI: 10.1016/j.bmcl.2007.07.100

Experimental method

X-RAY DIFFRACTION (2.3 Å)