2QOE

Human Dipeptidyl Peptidase IV in complex with a Triazolopiperazine-based beta amino acid Inhibitor

Summary for 2QOE

Entry DOI	10.2210/pdb2qoe/pdb
Descriptor	Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	alpha/beta inhibitors, beta-propeller, dimer, diabetes, aminopeptidase, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	174523.41
Authors	Scapin, G. (deposition date: 2007-07-20, release date: 2007-11-06, Last modification date: 2021-10-20)
Primary citation	Kowalchick, J.E.,Leiting, B.,Pryor, K.D.,Marsilio, F.,Wu, J.K.,He, H.,Lyons, K.A.,Eiermann, G.J.,Petrov, A.,Scapin, G.,Patel, R.A.,Thornberry, N.A.,Weber, A.E.,Kim, D. Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorg.Med.Chem.Lett., 17:5934-5939, 2007 Cited by PubMed: 17827003 DOI: 10.1016/j.bmcl.2007.07.100 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation