2QJB
Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB
Summary for 2QJB
Entry DOI | 10.2210/pdb2qjb/pdb |
Related | 1ES7 1REW 2QJ9 2QJA 3BMP |
Descriptor | Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | ligand-receptor complex, chondrogenesis, cleavage on pair of basic residues, cytokine, developmental protein, differentiation, glycoprotein, growth factor, osteogenesis, atp-binding, disease mutation, kinase, magnesium, manganese, membrane, metal-binding, nucleotide-binding, phosphorylation, serine/threonine-protein kinase, transferase, transmembrane, cytokine-receptor complex, cytokine/receptor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P12643 Membrane; Single-pass type I membrane protein: P36894 |
Total number of polymer chains | 4 |
Total formula weight | 55828.71 |
Authors | Kotzsch, A.,Mueller, T.D. (deposition date: 2007-07-06, release date: 2008-01-15, Last modification date: 2023-08-30) |
Primary citation | Kotzsch, A.,Nickel, J.,Seher, A.,Heinecke, K.,van Geersdaele, L.,Herrmann, T.,Sebald, W.,Mueller, T.D. Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283:5876-5887, 2008 Cited by PubMed: 18160401DOI: 10.1074/jbc.M706029200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report