2QJB
Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Bone morphogenetic protein 2 | polymer | 116 | 13126.1 | 2 | UniProt (P12643) Pfam (PF00019) In PDB | Homo sapiens (human) | BMP-2, BMP-2A |
2 | C, D | Bone morphogenetic protein receptor type IA | polymer | 135 | 14770.5 | 2 | UniProt (P36894) Pfam (PF01064) In PDB | Homo sapiens (human) | Serine/threonine-protein kinase receptor R5, SKR5, Activin receptor-like kinase 3, ALK-3, CD292 antigen |
3 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
4 | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 114 (UniProt: P12643)
C, D: 1 - 129 (UniProt: P36894)
PDB | External Database | Details |
---|---|---|
Met -1 | - | expression tag |
Ala 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -5 | - | expression tag |
Ser -4 | - | expression tag |
Gly -3 | - | expression tag |
Ala -2 | - | expression tag |
Met -1 | - | expression tag |
Ala 0 | - | expression tag |
His 42 | Gly 65 | engineered mutation |
Glu 46 | Asp 69 | engineered mutation |
Thr 61 | Ala 84 | engineered mutation |
Met 62 | Ile 85 | engineered mutation |
Thr 74 | Ala 97 | engineered mutation |
Leu 78 | Met 101 | engineered mutation |
Gly 79 | Lys 102 | engineered mutation |
Leu 80 | Tyr 103 | engineered mutation |
Arg 88 | Lys 111 | engineered mutation |
Thr 90 | Ser 113 | engineered mutation |
Ile 92 | Lys 115 | engineered mutation |
Pro 93 | Ala 116 | engineered mutation |
His 94 | Gln 117 | engineered mutation |
Gln 95 | Leu 118 | engineered mutation |
Ser 98 | Thr 121 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 55793.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 35.5 | |
All* | Total formula weight | 55828.7 |