2QJB

Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Bone morphogenetic protein 2	polymer	116	13126.1	2	UniProt (P12643) Pfam (PF00019)	Homo sapiens (human)	BMP-2, BMP-2A
2	C, D (C, D)	Bone morphogenetic protein receptor type IA	polymer	135	14770.5	2	UniProt (P36894) Pfam (PF01064)	Homo sapiens (human)	Serine/threonine-protein kinase receptor R5, SKR5, Activin receptor-like kinase 3, ALK-3, CD292 antigen
3	E (B)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
4	F, G, H, I (A, B, C, D)	water	water		18.0	79	Chemie (HOH)

Sequence modifications

A, B: 1 - 114 (UniProt: P12643)

PDB	External Database	Details
Met -1	-	expression tag
Ala 0	-	expression tag

C, D: 1 - 129 (UniProt: P36894)

PDB	External Database	Details
Gly -5	-	expression tag
Ser -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag
His 42	Gly 65	engineered mutation
Glu 46	Asp 69	engineered mutation
Thr 61	Ala 84	engineered mutation
Met 62	Ile 85	engineered mutation
Thr 74	Ala 97	engineered mutation
Leu 78	Met 101	engineered mutation
Gly 79	Lys 102	engineered mutation
Leu 80	Tyr 103	engineered mutation
Arg 88	Lys 111	engineered mutation
Thr 90	Ser 113	engineered mutation
Ile 92	Lys 115	engineered mutation
Pro 93	Ala 116	engineered mutation
His 94	Gln 117	engineered mutation
Gln 95	Leu 118	engineered mutation
Ser 98	Thr 121	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	55793.3
Non-Polymers*	Number of molecules	1
	Total formula weight	35.5
All*	Total formula weight	55828.7

*Water molecules are not included.