2QI0

Crystal structure of protease inhibitor, MIT-1-KK80 in complex with wild type HIV-1 protease

2QI0 の概要

• エントリーDOI: 10.2210/pdb2qi0/pdb
• 関連するPDBエントリー: 2QHY 2QHZ 2QI1 2QI3 2QI4 2QI5 2QI6 2QI7
• 分子名称: Protease, PHOSPHATE ION, N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[(3-METHOXYPHENYL)SULFONYL](2-THIENYLMETHYL)AMINO}PROPYL]-3-FLUORO-2-METHYLBENZAMIDE, ... (4 entities in total)
• 機能のキーワード: drug design, hiv-1 protease, protease inhibitors, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22309.26

構造登録者

Schiffer, C.A.,Nalam, M.N.L. (登録日: 2007-07-03, 公開日: 2008-04-22, 最終更新日: 2023-08-30)

• 主引用文献: Altman, M.D.,Ali, A.,Reddy, G.S.,Nalam, M.N.,Anjum, S.G.,Cao, H.,Chellappan, S.,Kairys, V.,Fernandes, M.X.,Gilson, M.K.,Schiffer, C.A.,Rana, T.M.,Tidor, B.; HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.; J.Am.Chem.Soc., 130:6099-6113, 2008; PubMed: 18412349; DOI: 10.1021/ja076558p

実験手法

X-RAY DIFFRACTION (2.1 Å)