2QG0

HSP90 complexed with A943037

2QG0 の概要

関連するPDBエントリー2QF6 2QFO
分子名称Heat shock protein HSP 90-alpha, N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE (3 entities in total)
機能のキーワードprotein-inhibitor complex, chaperone
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm P07900
ポリマー鎖数2
分子量合計47047.3
構造登録者
Park, C.H. (登録日: 2007-06-28, 公開日: 2008-07-01, 最終更新日: 2011-07-13)
主引用文献
Huth, J.R.,Park, C.,Petros, A.M.,Kunzer, A.R.,Wendt, M.D.,Wang, X.,Lynch, C.L.,Mack, J.C.,Swift, K.M.,Judge, R.A.,Chen, J.,Richardson, P.L.,Jin, S.,Tahir, S.K.,Matayoshi, E.D.,Dorwin, S.A.,Ladror, U.S.,Severin, J.M.,Walter, K.A.,Bartley, D.M.,Fesik, S.W.,Elmore, S.W.,Hajduk, P.J.
Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
Chem.Biol.Drug Des., 70:1-12, 2007
PubMed: 17630989 (主引用文献が同じPDBエントリー)
DOI: 10.1111/j.1747-0285.2007.00535.x
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.85 Å)
NMR情報
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers190.5%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード