2QFB

Crystal structure of the regulatory domain of human RIG-I with bound Zn

Summary for 2QFB

• Entry DOI: 10.2210/pdb2qfb/pdb
• Related: 2QFD
• Descriptor: Probable ATP-dependent RNA helicase DDX58, ZINC ION (3 entities in total)
• Functional Keywords: zinc finger, alternative splicing, antiviral defense, atp-binding, helicase, hydrolase, immune response, innate immunity, interferon induction, nucleotide-binding, polymorphism, rna-binding, ubl conjugation
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: O95786
• Total number of polymer chains: 10
• Total formula weight: 169189.07

Authors

Cui, S.,Lammens, A.,Lammens, K.,Hopfner, K.P. (deposition date: 2007-06-27, release date: 2008-02-12, Last modification date: 2023-08-30)

• Primary citation: Cui, S.,Eisenacher, K.,Kirchhofer, A.,Brzozka, K.,Lammens, A.,Lammens, K.,Fujita, T.,Conzelmann, K.K.,Krug, A.,Hopfner, K.P.; The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I.; Mol.Cell, 29:169-179, 2008; PubMed: 18243112; DOI: 10.1016/j.molcel.2007.10.032

Experimental method

X-RAY DIFFRACTION (3 Å)