2QEX

Negamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal Subunit

Summary for 2QEX

Entry DOI	10.2210/pdb2qex/pdb
Descriptor	23S ribosomal RNA, 50S ribosomal protein L10e, 50S ribosomal protein L13P, ... (38 entities in total)
Functional Keywords	large ribosomal subunit, 50s, negamycin, haloarcula marismortui, ribosome
Biological source	Haloarcula marismortui More
Cellular location	Cytoplasm : P12743
Total number of polymer chains	31
Total formula weight	1431015.30
Authors	Schroeder, S.J.,Blaha, G. (deposition date: 2007-06-26, release date: 2008-09-30, Last modification date: 2023-08-30)
Primary citation	Schroeder, S.J.,Blaha, G.,Moore, P.B. Negamycin binds to the wall of the nascent chain exit tunnel of the 50S ribosomal subunit. Antimicrob.Agents Chemother., 51:4462-4465, 2007 Cited by PubMed Abstract: Negamycin, a small-molecule inhibitor of protein synthesis, binds the Haloarcula marismortui 50S ribosomal subunit at a single site formed by highly conserved RNA nucleotides near the cytosolic end of the nascent chain exit tunnel. The mechanism of antibiotic action and the function of this unexplored tunnel region remain intriguingly elusive. PubMed: 17664317 DOI: 10.1128/AAC.00455-07 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation