2QCS

A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state

2QCS の概要

• エントリーDOI: 10.2210/pdb2qcs/pdb
• 関連するPDBエントリー: 1APM 1NE4 1NE6 1RGS
• 分子名称: cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase type I-alpha regulatory subunit, MANGANESE (II) ION, ... (9 entities in total)
• 機能のキーワード: cyclic adenosine monophosphate, camp-dependent protein kinase, pka holoenzyme, cyclic nucleotide binding domain, protein-protein interaction, conformational change, protein binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Cytoplasm . Isoform 2: Cell projection, cilium, flagellum : P05132; Cell membrane : P00514
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75151.43

構造登録者

Kim, C.,Cheng, C.Y.,Saldanha, A.S.,Taylor, S.S. (登録日: 2007-06-19, 公開日: 2007-11-06, 最終更新日: 2023-08-30)

• 主引用文献: Kim, C.,Cheng, C.Y.,Saldanha, S.A.,Taylor, S.S.; PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation.; Cell(Cambridge,Mass.), 130:1032-1043, 2007; PubMed: 17889648; DOI: 10.1016/j.cell.2007.07.018

実験手法

X-RAY DIFFRACTION (2.2 Å)