2QCI
HIV-1 Protease mutant D30N with potent Antiviral inhibitor GRL-98065
Summary for 2QCI
Entry DOI | 10.2210/pdb2qci/pdb |
Related | 2QD6 2QD7 2QD8 2Z4O |
Descriptor | Protease, SODIUM ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | hiv-1, mutant d30n, protease inhibitor, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22208.98 |
Authors | Wang, Y.F.,Tie, Y.,Boross, P.I.,Tozser, J.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. (deposition date: 2007-06-19, release date: 2008-04-22, Last modification date: 2023-10-25) |
Primary citation | Wang, Y.F.,Tie, Y.,Boross, P.I.,Tozser, J.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease. J.Med.Chem., 50:4509-4515, 2007 Cited by PubMed: 17696515DOI: 10.1021/jm070482q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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