2QA6

Crystal Structure of Estrogen Receptor Alpha mutant 537S Complexed with 4-(6-hydroxy-1H-indazol-3-yl)benzene-1,3-diol

Summary for 2QA6

Entry DOI	10.2210/pdb2qa6/pdb
Related	2QA8 2QAB
Descriptor	Estrogen receptor, nuclear receptor coactivator 2, 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL, ... (4 entities in total)
Functional Keywords	protein-ligand complex, transcription
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 Nucleus : Q8BN74
Total number of polymer chains	4
Total formula weight	62417.41
Authors	Nettles, K.W.,Bruning, J.B.,Nowak, J.,Sharma, S.K.,Hahm, J.B.,Shi, Y.,Kulp, K.,Hochberg, R.B.,Zhou, H.,Katzenellenbogen, J.A.,Katzenellenbogen, B.S.,Kim, Y.,Joachmiak, A.,Greene, G.L. (deposition date: 2007-06-14, release date: 2008-03-18, Last modification date: 2024-02-21)
Primary citation	Nettles, K.W.,Bruning, J.B.,Gil, G.,Nowak, J.,Sharma, S.K.,Hahm, J.B.,Kulp, K.,Hochberg, R.B.,Zhou, H.,Katzenellenbogen, J.A.,Katzenellenbogen, B.S.,Kim, Y.,Joachmiak, A.,Greene, G.L. NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Nat.Chem.Biol., 4:241-247, 2008 Cited by PubMed: 18344977 DOI: 10.1038/nchembio.76 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation