2QA6
Crystal Structure of Estrogen Receptor Alpha mutant 537S Complexed with 4-(6-hydroxy-1H-indazol-3-yl)benzene-1,3-diol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Estrogen receptor | polymer | 258 | 29386.6 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha |
| 2 | C, D | nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q8BN74) UniProt (by SIFTS) (Q61026) In PDB | Mus Musculus | |
| 3 | A, B | 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL | non-polymer | 242.2 | 2 | Chemie (KN2) | |||
| 4 | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A, B: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 297 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61932.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 484.5 | |
| All* | Total formula weight | 62417.4 |
