2QA6

Crystal Structure of Estrogen Receptor Alpha mutant 537S Complexed with 4-(6-hydroxy-1H-indazol-3-yl)benzene-1,3-diol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Estrogen receptor	polymer	258	29386.6	2	UniProt (P03372) Pfam (PF00104)	Homo sapiens (human)	ER, Estradiol receptor, ER-alpha
2	C, D (C, D)	nuclear receptor coactivator 2	polymer	13	1579.9	2	UniProt (Q8BN74) UniProt (by SIFTS) (Q61026)	Mus Musculus
3	E, F (A, B)	4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL	non-polymer		242.2	2	Chemie (KN2)
4	G, H (A, B)	water	water		18.0	41	Chemie (HOH)

Sequence modifications

A, B: 298 - 554 (UniProt: P03372)

PDB	External Database	Details
Ser 297	-	expression tag
Ser 537	Tyr 537	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	61932.9
Non-Polymers*	Number of molecules	2
	Total formula weight	484.5
All*	Total formula weight	62417.4

*Water molecules are not included.