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2Q9F

Crystal structure of human cytochrome P450 46A1 in complex with cholesterol-3-sulphate

Summary for 2Q9F
Entry DOI10.2210/pdb2q9f/pdb
Related2q9g
DescriptorCytochrome P450 46A1, PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
Functional Keywordscyp46a1, p450 46a1, p450, monooxygenase, cholesterol metabolic enzyme, oxidoreductase, heme, cholesterol-3-sulphate
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane; Single-pass membrane protein: Q9Y6A2
Total number of polymer chains1
Total formula weight53855.82
Authors
White, M.A.,Mast, N.V.,Johnson, E.F.,Stout, C.D.,Pikuleva, I.A. (deposition date: 2007-06-12, release date: 2008-06-17, Last modification date: 2024-02-21)
Primary citationMast, N.,White, M.A.,Bjorkhem, I.,Johnson, E.F.,Stout, C.D.,Pikuleva, I.A.
Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.
Proc.Natl.Acad.Sci.Usa, 105:9546-9551, 2008
Cited by
PubMed: 18621681
DOI: 10.1073/pnas.0803717105
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

数据于2024-03-27公开中

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