2Q9F
Crystal structure of human cytochrome P450 46A1 in complex with cholesterol-3-sulphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006699 | biological_process | bile acid biosynthetic process |
| A | 0006707 | biological_process | cholesterol catabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0007399 | biological_process | nervous system development |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0008207 | biological_process | C21-steroid hormone metabolic process |
| A | 0008395 | molecular_function | steroid hydroxylase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016125 | biological_process | sterol metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0030425 | cellular_component | dendrite |
| A | 0033781 | molecular_function | cholesterol 24-hydroxylase activity |
| A | 0042448 | biological_process | progesterone metabolic process |
| A | 0042995 | cellular_component | cell projection |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050649 | molecular_function | testosterone 6-beta-hydroxylase activity |
| A | 0062184 | molecular_function | testosterone 16-beta-hydroxylase activity |
| A | 0065008 | biological_process | regulation of biological quality |
| A | 0098793 | cellular_component | presynapse |
| A | 0098794 | cellular_component | postsynapse |
| A | 1900271 | biological_process | regulation of long-term synaptic potentiation |
| A | 1903044 | biological_process | protein localization to membrane raft |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 601 |
| Chain | Residue |
| A | GLY198 |
| A | MET199 |
| A | ARG261 |
| A | HOH786 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEM A 602 |
| Chain | Residue |
| A | PHE299 |
| A | ALA302 |
| A | GLY303 |
| A | THR306 |
| A | SER307 |
| A | ALA367 |
| A | THR370 |
| A | PRO429 |
| A | PHE430 |
| A | SER431 |
| A | ARG435 |
| A | CYS437 |
| A | ILE438 |
| A | PHE442 |
| A | ALA443 |
| A | HOH712 |
| A | HOH715 |
| A | HOH732 |
| A | LYS104 |
| A | TYR109 |
| A | LEU125 |
| A | TRP134 |
| A | ARG138 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE C3S A 600 |
| Chain | Residue |
| A | PHE80 |
| A | HIS81 |
| A | MET108 |
| A | TYR109 |
| A | ARG110 |
| A | ARG226 |
| A | ASN227 |
| A | ALA474 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 931 |
| Chain | Residue |
| A | SER92 |
| A | LYS94 |
| A | LYS95 |
| A | ASP381 |
| A | HOH763 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 932 |
| Chain | Residue |
| A | TRP67 |
| A | GLU334 |
| A | ARG349 |
| A | GLN351 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 933 |
| Chain | Residue |
| A | ASN78 |
| A | PHE80 |
| A | LYS82 |
| A | THR83 |
| A | SER338 |
| A | LYS339 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 934 |
| Chain | Residue |
| A | PRO423 |
| A | PHE425 |
| A | HOH737 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 935 |
| Chain | Residue |
| A | MET183 |
| A | LEU204 |
| A | LYS209 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 936 |
| Chain | Residue |
| A | LYS171 |
| A | SER179 |
| A | ASP182 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSlGHRSCIG |
| Chain | Residue | Details |
| A | PHE430-GLY439 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:18621681, ECO:0000269|PubMed:20667828, ECO:0000269|PubMed:23288837, ECO:0007744|PDB:2Q9F, ECO:0007744|PDB:2Q9G, ECO:0007744|PDB:3MDR, ECO:0007744|PDB:3MDT, ECO:0007744|PDB:3MDV, ECO:0007744|PDB:4ENH, ECO:0007744|PDB:4FIA, ECO:0007744|PDB:4J14 |
| Chain | Residue | Details |
| A | CYS437 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1akd |
| Chain | Residue | Details |
| A | THR306 | |
| A | GLU305 |
