2Q8G
Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD7545
Summary for 2Q8G
Entry DOI | 10.2210/pdb2q8g/pdb |
Related | 2Q8F 2Q8H 2Q8I |
Descriptor | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, POTASSIUM ION, 4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE, ... (4 entities in total) |
Functional Keywords | ghkl atpase/kinase family, pyruvate dehydrogenase complex, mitochondrial kinase, glucose-lowering drug azd7545, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion matrix : Q15118 |
Total number of polymer chains | 1 |
Total formula weight | 46879.58 |
Authors | Kato, M.,Li, J.,Chuang, J.L.,Chuang, D.T. (deposition date: 2007-06-10, release date: 2007-07-24, Last modification date: 2024-03-13) |
Primary citation | Kato, M.,Li, J.,Chuang, J.L.,Chuang, D.T. Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol. Structure, 15:992-1004, 2007 Cited by PubMed: 17683942DOI: 10.1016/j.str.2007.07.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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