2Q8G
Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD7545
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1 | polymer | 407 | 46361.6 | 1 | UniProt (Q15118) Pfam (PF10436) Pfam (PF02518) | Homo sapiens (human) | Pyruvate dehydrogenase kinase isoform 1 |
| 2 | B (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 3 | C (A) | 4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE | non-polymer | 478.9 | 1 | Chemie (AZX) | |||
| 4 | D (A) | water | water | 18.0 | 315 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 46361.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 518.0 | |
| All* | Total formula weight | 46879.6 |
