2Q8G

Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD7545

2Q8G の概要

• エントリーDOI: 10.2210/pdb2q8g/pdb
• 関連するPDBエントリー: 2Q8F 2Q8H 2Q8I
• 分子名称: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, POTASSIUM ION, 4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE, ... (4 entities in total)
• 機能のキーワード: ghkl atpase/kinase family, pyruvate dehydrogenase complex, mitochondrial kinase, glucose-lowering drug azd7545, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion matrix : Q15118
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46879.58

構造登録者

Kato, M.,Li, J.,Chuang, J.L.,Chuang, D.T. (登録日: 2007-06-10, 公開日: 2007-07-24, 最終更新日: 2024-03-13)

• 主引用文献: Kato, M.,Li, J.,Chuang, J.L.,Chuang, D.T.; Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol.; Structure, 15:992-1004, 2007; PubMed: 17683942; DOI: 10.1016/j.str.2007.07.001

実験手法

X-RAY DIFFRACTION (1.9 Å)