2Q62

Crystal Structure of ArsH from Sinorhizobium meliloti

2Q62 の概要

• エントリーDOI: 10.2210/pdb2q62/pdb
• 分子名称: arsH, SULFATE ION (3 entities in total)
• 機能のキーワード: alpha/beta, flavoprotein
• 由来する生物種: Sinorhizobium meliloti
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 224238.93

構造登録者

Ye, J.,Yang, H.,Bhattacharjee, H.,Rosen, B.P. (登録日: 2007-06-04, 公開日: 2007-12-11, 最終更新日: 2024-02-21)

主引用文献

Ye, J.,Yang, H.,Rosen, B.P.,Bhattacharjee, H.
Crystal structure of the flavoprotein ArsH from Sinorhizobium meliloti
FEBS Lett., 581:3996-4000, 2007

PubMed Abstract: Purified ArsH from Sinorhizobium meliloti exhibits NADPH:FMN-dependent reduction of molecular O2 to hydrogen peroxide and catalyzes reduction of azo dyes. The structure of ArsH was determined at 1.8A resolution. ArsH crystallizes with eight molecules in the asymmetric unit forming two tetramers. Each monomer has a core domain with a central five-stranded parallel beta-sheet and two monomers interact to form a classical flavodoxin-like dimer. The N- and C-terminal extensions of ArsH are involved in interactions between subunits and tetramer formation. The structure may provide insight in how ArsH participates in arsenic detoxification.

PubMed: 17673204
DOI: 10.1016/j.febslet.2007.07.039

実験手法

X-RAY DIFFRACTION (1.8 Å)