2Q20
Structure of the germline Vk1 O18/O8 light chain variable domain homodimer
Summary for 2Q20
Entry DOI | 10.2210/pdb2q20/pdb |
Related | 2Q1E |
Descriptor | Vk1 O18/O8 germline light chain variable domain (2 entities in total) |
Functional Keywords | vk1, germline, al, light chain amyloidosis, amyloid, immunoglobulin, light chain, light chain variable domain, protein fibril |
Biological source | Homo sapiens (human) |
Cellular location | Secreted : P01594 |
Total number of polymer chains | 2 |
Total formula weight | 23942.24 |
Authors | Thompson, J.R.,Ramirez-Alvarado, M.,Baden, E.M. (deposition date: 2007-05-25, release date: 2008-04-08, Last modification date: 2023-08-30) |
Primary citation | Baden, E.M.,Owen, B.A.,Peterson, F.C.,Volkman, B.F.,Ramirez-Alvarado, M.,Thompson, J.R. Altered dimer interface decreases stability in an amyloidogenic protein. J.Biol.Chem., 283:15853-15860, 2008 Cited by PubMed: 18400753DOI: 10.1074/jbc.M705347200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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