2PZ1
Crystal Structure of Auto-inhibited Asef
Summary for 2PZ1
Entry DOI | 10.2210/pdb2pz1/pdb |
Descriptor | Rho guanine nucleotide exchange factor 4 (2 entities in total) |
Functional Keywords | helical bundle, beta barrel, beta sandwich, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 3: Cytoplasm: Q9NR80 |
Total number of polymer chains | 1 |
Total formula weight | 53937.78 |
Authors | Betts, L.,Sondek, J.,Rossman, K.L. (deposition date: 2007-05-17, release date: 2007-08-21, Last modification date: 2024-02-21) |
Primary citation | Mitin, N.,Betts, L.,Yohe, M.E.,Der, C.J.,Sondek, J.,Rossman, K.L. Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nat.Struct.Mol.Biol., 14:814-823, 2007 Cited by PubMed: 17704816DOI: 10.1038/nsmb1290 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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