2PX6
Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat
Summary for 2PX6
Entry DOI | 10.2210/pdb2px6/pdb |
Descriptor | Thioesterase domain, (2S,3S,5S)-5-[(N-FORMYL-L-LEUCYL)OXY]-2-HEXYL-3-HYDROXYHEXADECANOIC ACID, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (4 entities in total) |
Functional Keywords | thioesaterse domain, orlistat, fatty acid synthase, drug complex, tetrahydrolipstatin, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P49327 |
Total number of polymer chains | 2 |
Total formula weight | 70644.16 |
Authors | Pemble IV, C.W.,Johnson, L.C.,Kridel, S.J.,Lowther, W.T. (deposition date: 2007-05-14, release date: 2007-07-10, Last modification date: 2023-08-30) |
Primary citation | Pemble, C.W.,Johnson, L.C.,Kridel, S.J.,Lowther, W.T. Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. Nat.Struct.Mol.Biol., 14:704-709, 2007 Cited by PubMed: 17618296DOI: 10.1038/nsmb1265 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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