2PX6

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

2PX6 の概要

• エントリーDOI: 10.2210/pdb2px6/pdb
• 分子名称: Thioesterase domain, (2S,3S,5S)-5-[(N-FORMYL-L-LEUCYL)OXY]-2-HEXYL-3-HYDROXYHEXADECANOIC ACID, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (4 entities in total)
• 機能のキーワード: thioesaterse domain, orlistat, fatty acid synthase, drug complex, tetrahydrolipstatin, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P49327
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70644.16

構造登録者

Pemble IV, C.W.,Johnson, L.C.,Kridel, S.J.,Lowther, W.T. (登録日: 2007-05-14, 公開日: 2007-07-10, 最終更新日: 2023-08-30)

• 主引用文献: Pemble, C.W.,Johnson, L.C.,Kridel, S.J.,Lowther, W.T.; Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat.; Nat.Struct.Mol.Biol., 14:704-709, 2007; PubMed: 17618296; DOI: 10.1038/nsmb1265

実験手法

X-RAY DIFFRACTION (2.3 Å)