2PX4
Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAH (Monoclinic form 2)
Summary for 2PX4
Entry DOI | 10.2210/pdb2px4/pdb |
Related | 2PX2 2PX5 2PX8 2PXA 2PXC |
Descriptor | Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], CHLORIDE ION, SULFATE ION, ... (7 entities in total) |
Functional Keywords | murray valley encephalitis virus, methyltransferase, sah, structural genomics, oxford protein production facility, oppf, transferase |
Biological source | Murray valley encephalitis virus (strain MVE-1-51) |
Cellular location | Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P05769 |
Total number of polymer chains | 1 |
Total formula weight | 31562.16 |
Authors | Assenberg, R.,Ren, J.,Verma, A.,Walter, T.S.,Alderton, D.,Hurrelbrink, R.J.,Fuller, S.D.,Owens, R.J.,Stuart, D.I.,Grimes, J.M.,Oxford Protein Production Facility (OPPF) (deposition date: 2007-05-14, release date: 2007-05-29, Last modification date: 2023-08-30) |
Primary citation | Assenberg, R.,Ren, J.,Verma, A.,Walter, T.S.,Alderton, D.,Hurrelbrink, R.J.,Fuller, S.D.,Bressanelli, S.,Owens, R.J.,Stuart, D.I.,Grimes, J.M. Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. J.Gen.Virol., 88:2228-2236, 2007 Cited by PubMed: 17622627DOI: 10.1099/vir.0.82757-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report