2PWT

Crystal structure of the bacterial ribosomal decoding site complexed with aminoglycoside containing the L-HABA group

Summary for 2PWT

Entry DOI	10.2210/pdb2pwt/pdb
Descriptor	22-mer of the ribosomal decoding site, DOUBLY FUNCTIONALIZED PAROMOMYCIN PM-II-162 (3 entities in total)
Functional Keywords	aminoglycoside; haba group; ribosomal decoding site; x-ray analysis; rna, rna-antibiotic complex, rna/antibiotic
Total number of polymer chains	2
Total formula weight	16078.00
Authors	Kondo, J.,Pachamuthu, K.,Francois, B.,Szychowski, J.,Hanessian, S.,Westhof, E. (deposition date: 2007-05-13, release date: 2007-09-18, Last modification date: 2024-03-13)
Primary citation	Kondo, J.,Pachamuthu, K.,Francois, B.,Szychowski, J.,Hanessian, S.,Westhof, E. Crystal Structure of the Bacterial Ribosomal Decoding Site Complexed with a Synthetic Doubly Functionalized Paromomycin Derivative: a New Specific Binding Mode to an A-Minor Motif Enhances in vitro Antibacterial Activity Chemmedchem, 2:1631-1638, 2007 Cited by PubMed: 17722211 DOI: 10.1002/cmdc.200700113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation