2PT9

The structure of Plasmodium falciparum spermidine synthase in complex with decarboxylated S-adenosylmethionine and the inhibitor cis-4-methylcyclohexylamine (4MCHA)

2PT9 の概要

• エントリーDOI: 10.2210/pdb2pt9/pdb
• 関連するPDBエントリー: 2HTE 2I7C 2PSS 2PT6
• 分子名称: Spermidine synthase, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, cis-4-methylcyclohexanamine, ... (7 entities in total)
• 機能のキーワード: transferase, spermidine synthase, structural genomics consortium, sgc, inhibitor complex, structural biology of malarial parasites and other apicomplexans
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 112207.28

構造登録者

Dufe, V.T.,Qiu, W.,Muller, I.B.,Hui, R.,Walter, R.D.,Al-Karadaghi, S.,Structural Genomics Consortium (SGC) (登録日: 2007-05-08, 公開日: 2008-04-01, 最終更新日: 2023-08-30)

• 主引用文献: Dufe, V.T.,Qiu, W.,Muller, I.B.,Hui, R.,Walter, R.D.,Al-Karadaghi, S.; Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.; J.Mol.Biol., 373:167-177, 2007; PubMed: 17822713; DOI: 10.1016/j.jmb.2007.07.053

実験手法

X-RAY DIFFRACTION (2.2 Å)