2PRM
The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site
Summary for 2PRM
Entry DOI | 10.2210/pdb2prm/pdb |
Related | 1D3G 2PRH 2PRL |
Descriptor | Dihydroorotate dehydrogenase, mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (4 entities in total) |
Functional Keywords | protein inhibitor complex, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion inner membrane ; Single-pass membrane protein : Q02127 |
Total number of polymer chains | 1 |
Total formula weight | 40468.97 |
Authors | Walse, B.,Dufe, V.T.,Al-Karadaghi, S. (deposition date: 2007-05-04, release date: 2008-05-20, Last modification date: 2023-08-30) |
Primary citation | Walse, B.,Dufe, V.T.,Svensson, B.,Fritzson, I.,Dahlberg, L.,Khairoullina, A.,Wellmar, U.,Al-Karadaghi, S. The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites Biochemistry, 47:8929-8936, 2008 Cited by PubMed: 18672895DOI: 10.1021/bi8003318 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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