2PR3

Factor XA inhibitor

Summary for 2PR3

• Entry DOI: 10.2210/pdb2pr3/pdb
• Related: 2G0M 2G21 2PHB
• Descriptor: COAGULATION FACTOR X, HEAVY CHAIN, COAGULATION FACTOR X, LIGHT CHAIN, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: fxa coagulation factor inhibitor, blood clotting
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32533.32

Authors

Zhang, E.,Kohrt, J.T.,Bigge, C.F.,Finzel, B.C. (deposition date: 2007-05-03, release date: 2007-08-14, Last modification date: 2017-10-18)

• Primary citation: Van Huis, C.A.,Bigge, C.F.,Casimiro-Garcia, A.,Cody, W.L.,Dudley, D.A.,Filipski, K.J.,Heemstra, R.J.,Kohrt, J.T.,Narasimhan, L.S.,Schaum, R.P.,Zhang, E.,Bryant, J.W.,Haarer, S.,Janiczek, N.,Leadley, R.J.,McClanahan, T.,Thomas Peterson, J.,Welch, K.M.,Edmunds, J.J.; Structure-based drug design of pyrrolidine-1, 2-dicarboxamides as a novel series of orally bioavailable factor Xa inhibitors; Chem.Biol.Drug Des., 69:444-450, 2007; PubMed: 17581239; DOI: 10.1111/j.1747-0285.2007.00520.x

Experimental method

X-RAY DIFFRACTION (1.5 Å)