2PQF

Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment in complex with an inhibitor 3-Aminobenzoic acid

2PQF の概要

• エントリーDOI: 10.2210/pdb2pqf/pdb
• 分子名称: Poly [ADP-ribose] polymerase 12, 3-AMINOBENZOIC ACID, CITRIC ACID, ... (4 entities in total)
• 機能のキーワード: enzyme-inhibitor complex, catalytic fragment, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q9H0J9
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 138919.48

構造登録者

Karlberg, T.,Lehtio, L.,Arrowsmith, C.H.,Berglund, H.,Busam, R.D.,Collins, R.,Dahlgren, L.G.,Edwards, A.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hogbom, M.,Johansson, I.,Kallas, A.,Kotenyova, T.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Sundstrom, M.,Thorsell, A.G.,Van Den Berg, S.,Weigelt, J.,Holmberg-Schiavone, L.,Structural Genomics Consortium (SGC) (登録日: 2007-05-02, 公開日: 2007-05-15, 最終更新日: 2015-04-22)

• 主引用文献: Karlberg, T.,Klepsch, M.,Thorsell, A.G.,Andersson, C.D.,Linusson, A.,Schuler, H.; Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein.; J.Biol.Chem., 290:7336-7344, 2015; PubMed: 25635049; DOI: 10.1074/jbc.M114.630160

実験手法

X-RAY DIFFRACTION (2.2 Å)