2PQ9

E. coli EPSPS liganded with (R)-difluoromethyl tetrahedral reaction intermediate analog

Summary for 2PQ9

Entry DOI	10.2210/pdb2pq9/pdb
Related	1g6s 1g6t 1q36 1x8r 1x8t 2PQB 2PQC 2PQD
Descriptor	3-phosphoshikimate 1-carboxyvinyltransferase, (3R,4S,5R)-5-[(1R)-1-CARBOXY-2,2-DIFLUORO-1-(PHOSPHONOOXY)ETHOXY]-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID, FORMIC ACID, ... (4 entities in total)
Functional Keywords	inside-out alpha/beta barrel, transferase
Biological source	Escherichia coli
Cellular location	Cytoplasm (Probable): P0A6D3
Total number of polymer chains	1
Total formula weight	47244.12
Authors	Healy-Fried, M.L.,Funke, T.,Han, H.,Schonbrunn, E. (deposition date: 2007-05-01, release date: 2008-03-11, Last modification date: 2023-08-30)
Primary citation	Funke, T.,Healy-Fried, M.L.,Han, H.,Alberg, D.G.,Bartlett, P.A.,Schonbrunn, E. Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analogues. Biochemistry, 46:13344-13351, 2007 Cited by PubMed: 17958399 DOI: 10.1021/bi701095u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation