2POB

PPARgamma Ligand binding domain complexed with a farglitazar analogue gw4709

Summary for 2POB

Entry DOI	10.2210/pdb2pob/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, N-[(2S)-2-[(2-BENZOYLPHENYL)AMINO]-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL]ACETAMIDE, GLYCEROL, ... (4 entities in total)
Functional Keywords	pparg, nuclear receptor, ppar, gene regulation
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	62854.04
Authors	Nolte, R.T. (deposition date: 2007-04-26, release date: 2008-03-18, Last modification date: 2024-04-03)
Primary citation	Trump, R.P.,Cobb, J.E.,Shearer, B.G.,Lambert, M.H.,Nolte, R.T.,Willson, T.M.,Buckholtz, R.G.,Zhao, S.M.,Leesnitzer, L.M.,Iannone, M.A.,Pearce, K.H.,Billin, A.N.,Hoekstra, W.J. Cocrystal structure guided array synthesis of PPARgamma inverse agonists BIOORG.MED.CHEM.LETT., 17:3916-3920, 2007 Cited by PubMed: 17533125 DOI: 10.1016/j.bmcl.2007.04.111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation