2PO3

Crystal Structure Analysis of DesI in the presence of its TDP-sugar product

Summary for 2PO3

Entry DOI	10.2210/pdb2po3/pdb
Descriptor	4-dehydrase, (2R,3R,4S,5S,6R)-3,4-DIHYDROXY-5-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)IMINO]-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL [(2R,3S,5R)-3-HYDROXY-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE (3 entities in total)
Functional Keywords	external aldimine, plp, aminotransferase, tdp-sugar, transferase
Biological source	Streptomyces venezuelae
Total number of polymer chains	2
Total formula weight	92513.14
Authors	Burgie, E.S.,Holden, H.M. (deposition date: 2007-04-25, release date: 2007-08-14, Last modification date: 2023-08-30)
Primary citation	Burgie, E.S.,Holden, H.M. Molecular Architecture of DesI: A Key Enzyme in the Biosynthesis of Desosamine Biochemistry, 46:8999-9006, 2007 Cited by PubMed: 17630700 DOI: 10.1021/bi700751d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation