2PMN

Crystal structure of PfPK7 in complex with an ATP-site inhibitor

2PMN の概要

• エントリーDOI: 10.2210/pdb2pmn/pdb
• 分子名称: Ser/Thr protein kinase, putative, 4-(6-{[(1S)-1-(HYDROXYMETHYL)-2-METHYLPROPYL]AMINO}IMIDAZO[1,2-B]PYRIDAZIN-3-YL)BENZONITRILE (3 entities in total)
• 機能のキーワード: ser/thr protein kinase; plasmodium falciparum; transferase; phosphorylation, transferase
• 由来する生物種: Plasmodium falciparum (malaria parasite P. falciparum)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41755.97

構造登録者

Merckx, A.,Echalier, A.,Noble, M.,Endicott, J. (登録日: 2007-04-23, 公開日: 2008-01-22, 最終更新日: 2023-08-30)

• 主引用文献: Merckx, A.,Echalier, A.,Langford, K.,Sicard, A.,Langsley, G.,Joore, J.,Doerig, C.,Noble, M.,Endicott, J.; Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design.; Structure, 16:228-238, 2008; PubMed: 18275814; DOI: 10.1016/j.str.2007.11.014

実験手法

X-RAY DIFFRACTION (2.8 Å)