2PJL

Crystal Structure of Human Estrogen-Related Receptor alpha in Complex with a Synthetic Inverse Agonist reveals its Novel Molecular Mechanism

Summary for 2PJL

• Entry DOI: 10.2210/pdb2pjl/pdb
• Related: 1XB7
• Descriptor: Steroid hormone receptor ERR1, 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE (3 entities in total)
• Functional Keywords: nuclear hormone receptor, ligand binding domain, ligand binding pocket, three-layered alpha-helical sandwich, inverse agonist, helix 12 (h12), coactivator groove, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P11474
• Total number of polymer chains: 2
• Total formula weight: 54699.16

Authors

Kallen, J. (deposition date: 2007-04-16, release date: 2007-06-12, Last modification date: 2023-08-30)

• Primary citation: Kallen, J.,Lattmann, R.,Beerli, R.,Blechschmidt, A.,Blommers, M.J.,Geiser, M.,Ottl, J.,Schlaeppi, J.M.,Strauss, A.,Fournier, B.; Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism.; J.Biol.Chem., 282:23231-23239, 2007; PubMed: 17556356; DOI: 10.1074/jbc.M703337200

Experimental method

X-RAY DIFFRACTION (2.3 Å)