2PHO

Crystal structure of human arginase I complexed with thiosemicarbazide at 1.95 resolution

Summary for 2PHO

Entry DOI	10.2210/pdb2pho/pdb
Related	2PHA
Descriptor	Arginase-1, MANGANESE (II) ION, HYDRAZINECARBOTHIOAMIDE, ... (4 entities in total)
Functional Keywords	thiosemicarbazide, fragment, inhibitor design, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P05089
Total number of polymer chains	2
Total formula weight	69870.65
Authors	Di Costanzo, L.,Christianson, D.W. (deposition date: 2007-04-11, release date: 2007-05-08, Last modification date: 2023-08-30)
Primary citation	Di Costanzo, L.,Pique, M.E.,Christianson, D.W. Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster. J.Am.Chem.Soc., 129:6388-6389, 2007 Cited by PubMed: 17469833 DOI: 10.1021/ja071567j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation