2PH8
Crystal Structure of Human Beta Secretase Complexed with inhibitor
Summary for 2PH8
Entry DOI | 10.2210/pdb2ph8/pdb |
Descriptor | Beta-secretase 1, SULFATE ION, N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE, ... (4 entities in total) |
Functional Keywords | aspartyl protease, bace, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 45774.48 |
Authors | Munshi, S. (deposition date: 2007-04-10, release date: 2008-04-22, Last modification date: 2023-08-30) |
Primary citation | Moore, K.P.,Zhu, H.,Rajapakse, H.A.,McGaughey, G.B.,Colussi, D.,Price, E.A.,Sankaranarayanan, S.,Simon, A.J.,Pudvah, N.T.,Hochman, J.H.,Allison, T.,Munshi, S.K.,Graham, S.L.,Vacca, J.P.,Nantermet, P.G. Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors. Bioorg.Med.Chem.Lett., 17:5831-5835, 2007 Cited by PubMed: 17827011DOI: 10.1016/j.bmcl.2007.08.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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