2PH6
Crystal Structure of Human Beta Secretase Complexed with inhibitor
Summary for 2PH6
Entry DOI | 10.2210/pdb2ph6/pdb |
Related | 1TQF |
Descriptor | Beta-secretase 1, SULFATE ION, 3-({[(1R)-1-(4-FLUOROPHENYL)ETHYL]AMINO}CARBONYL)-5-[METHYL(METHYLSULFONYL)AMINO]BENZYL ALPHA-METHYL-D-PHENYLALANINATE, ... (4 entities in total) |
Functional Keywords | aspartyl protease, bace, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 45760.45 |
Authors | Munshi, S. (deposition date: 2007-04-10, release date: 2007-06-05, Last modification date: 2023-08-30) |
Primary citation | Lindsley, S.R.,Moore, K.P.,Rajapakse, H.A.,Selnick, H.G.,Young, M.B.,Zhu, H.,Munshi, S.,Kuo, L.,McGaughey, G.B.,Colussi, D.,Crouthamel, M.C.,Lai, M.T.,Pietrak, B.,Price, E.A.,Sankaranarayanan, S.,Simon, A.J.,Seabrook, G.R.,Hazuda, D.J.,Pudvah, N.T.,Hochman, J.H.,Graham, S.L.,Vacca, J.P.,Nantermet, P.G. Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors. Bioorg.Med.Chem.Lett., 17:4057-4061, 2007 Cited by PubMed: 17482814DOI: 10.1016/j.bmcl.2007.04.072 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report