2PGZ
Crystal structure of Cocaine bound to an ACh-Binding Protein
Summary for 2PGZ
Entry DOI | 10.2210/pdb2pgz/pdb |
Descriptor | Soluble acetylcholine receptor, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COCAINE, ... (6 entities in total) |
Functional Keywords | non-competitive inhibitors, nicotinic acetycholine receptors, acetycholine-binding protein, benzodiazepine, galanthamine, cocaine, choline binding protein, choline-binding protein |
Biological source | Aplysia californica (California sea hare) |
Total number of polymer chains | 5 |
Total formula weight | 133381.94 |
Authors | Hansen, S.B.,Taylor, P. (deposition date: 2007-04-10, release date: 2007-07-03, Last modification date: 2023-08-30) |
Primary citation | Hansen, S.B.,Taylor, P. Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors. J.Mol.Biol., 369:895-901, 2007 Cited by PubMed: 17481657DOI: 10.1016/j.jmb.2007.03.067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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