2PGZ

Crystal structure of Cocaine bound to an ACh-Binding Protein

2PGZ の概要

• エントリーDOI: 10.2210/pdb2pgz/pdb
• 分子名称: Soluble acetylcholine receptor, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COCAINE, ... (6 entities in total)
• 機能のキーワード: non-competitive inhibitors, nicotinic acetycholine receptors, acetycholine-binding protein, benzodiazepine, galanthamine, cocaine, choline binding protein, choline-binding protein
• 由来する生物種: Aplysia californica (California sea hare)
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 133381.94

構造登録者

Hansen, S.B.,Taylor, P. (登録日: 2007-04-10, 公開日: 2007-07-03, 最終更新日: 2023-08-30)

• 主引用文献: Hansen, S.B.,Taylor, P.; Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors.; J.Mol.Biol., 369:895-901, 2007; PubMed: 17481657; DOI: 10.1016/j.jmb.2007.03.067

実験手法

X-RAY DIFFRACTION (1.76 Å)