2P93

Factor xa in complex with the inhibitor 5-chloro-N-(2-(4-(2-oxopyridin-1(2H)-yl)benzamido)ethyl)thiophene-2-carboxamide

2P93 の概要

• エントリーDOI: 10.2210/pdb2p93/pdb
• 関連するPDBエントリー: 2P94 2P95
• 分子名称: Factor Xa, 5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE, ... (4 entities in total)
• 機能のキーワード: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00742 P00742
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32438.20

構造登録者

Chang, C.-H. (登録日: 2007-03-23, 公開日: 2007-07-24, 最終更新日: 2017-10-18)

• 主引用文献: Qiao, J.X.,Chang, C.-H.,Cheney, D.L.,Morin, P.E.,Wang, G.Z.,King, S.R.,Wang, T.C.,Rendina, A.R.,Luettgen, J.M.,Knabb, R.M.,Wexler, R.R.,Lam, P.Y.S.; SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa; Bioorg.Med.Chem.Lett., 17:4419-4427, 2007; PubMed: 17588746; DOI: 10.1016/j.bmcl.2007.06.029

実験手法

X-RAY DIFFRACTION (1.9 Å)