2P8S

Human dipeptidyl peptidase IV/CD26 in complex with a cyclohexalamine inhibitor

Summary for 2P8S

Entry DOI	10.2210/pdb2p8s/pdb
Related	1X70
Descriptor	DIPEPTIDYL PEPTIDASE IV SOLUBLE FORM, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	alpha/beta, beta-propeller, dimer, structure-based design, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	174961.88
Authors	Scapin, G.,Biftu, T. (deposition date: 2007-03-23, release date: 2007-05-22, Last modification date: 2023-08-30)
Primary citation	Biftu, T.,Scapin, G.,Singh, S.,Feng, D.,Becker, J.W.,Eiermann, G.,He, H.,Lyons, K.,Patel, S.,Petrov, A.,Sinha-Roy, R.,Zhang, B.,Wu, J.,Zhang, X.,Doss, G.A.,Thornberry, N.A.,Weber, A.E. Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin Bioorg.Med.Chem.Lett., 17:3384-3387, 2007 Cited by PubMed: 17433672 DOI: 10.1016/j.bmcl.2007.03.095 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation