2P8S
Human dipeptidyl peptidase IV/CD26 in complex with a cyclohexalamine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DIPEPTIDYL PEPTIDASE IV SOLUBLE FORM | polymer | 728 | 84476.6 | 2 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) | Homo sapiens (human) | DPP IV, T-CELL ACTIVATION ANTIGEN CD26, TP103, ADENOSINE DEAMINASE COMPLEXING PROTEIN-2, ADABP |
| 2 | C, D, E, F, G... (C, D, E, F, G...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 9 | In PDB GlyTouCan (G42666HT) | |||
| 3 | L, M, N, Q, R... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 4 | O (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | P, T (A, B) | (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINE | non-polymer | 419.4 | 2 | Chemie (417) | |||
| 6 | U, V (A, B) | water | water | 18.0 | 995 | Chemie (HOH) |
Sequence modifications
A, B: 40 - 766 (UniProt: P27487)
| PDB | External Database | Details |
|---|---|---|
| Thr 39 | Ser 39 | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 168953.3 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 3819.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2189.0 | |
| All* | Total formula weight | 174961.9 |
