2P8S

Human dipeptidyl peptidase IV/CD26 in complex with a cyclohexalamine inhibitor

2P8S の概要

• エントリーDOI: 10.2210/pdb2p8s/pdb
• 関連するPDBエントリー: 1X70
• 分子名称: DIPEPTIDYL PEPTIDASE IV SOLUBLE FORM, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: alpha/beta, beta-propeller, dimer, structure-based design, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 174961.88

構造登録者

Scapin, G.,Biftu, T. (登録日: 2007-03-23, 公開日: 2007-05-22, 最終更新日: 2023-08-30)

• 主引用文献: Biftu, T.,Scapin, G.,Singh, S.,Feng, D.,Becker, J.W.,Eiermann, G.,He, H.,Lyons, K.,Patel, S.,Petrov, A.,Sinha-Roy, R.,Zhang, B.,Wu, J.,Zhang, X.,Doss, G.A.,Thornberry, N.A.,Weber, A.E.; Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin; Bioorg.Med.Chem.Lett., 17:3384-3387, 2007; PubMed: 17433672; DOI: 10.1016/j.bmcl.2007.03.095

実験手法

X-RAY DIFFRACTION (2.2 Å)