2P8H
Crystal structure of human beta secretase complexed with inhibitor
Summary for 2P8H
Entry DOI | 10.2210/pdb2p8h/pdb |
Descriptor | Beta-secretase 1, N-{(1S,2S)-1-BENZYL-2-HYDROXY-2-[(4S)-1,2,2-TRIMETHYL-5-OXOIMIDAZOLIDIN-4-YL]ETHYL}-N'-[(1R)-1-(4-FLUOROPHENYL)ETHYL]-5-[METHYL(METHYLSULFONYL)AMINO]ISOPHTHALAMIDE (3 entities in total) |
Functional Keywords | aspartyl protease, bace, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 45776.51 |
Authors | Munshi, S. (deposition date: 2007-03-22, release date: 2007-08-14, Last modification date: 2023-08-30) |
Primary citation | Barrow, J.C.,Rittle, K.E.,Ngo, P.L.,Selnick, H.G.,Graham, S.L.,Pitzenberger, S.M.,McGaughey, G.B.,Colussi, D.,Lai, M.T.,Huang, Q.,Tugusheva, K.,Espeseth, A.S.,Simon, A.J.,Munshi, S.K.,Vacca, J.P. Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1. Chemmedchem, 2:995-999, 2007 Cited by PubMed: 17458843DOI: 10.1002/cmdc.200700038 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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