2P7U

The crystal structure of rhodesain, the major cysteine protease of T. brucei rhodesiense, bound to inhibitor K777

2P7U の概要

• エントリーDOI: 10.2210/pdb2p7u/pdb
• 分子名称: Cysteine protease, NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE (3 entities in total)
• 機能のキーワード: cysteine protease, trypanosoma brucei, neglected disease, hydrolase
• 由来する生物種: Trypanosoma brucei rhodesiense
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23479.94

構造登録者

Brinen, L.S.,Marion, R. (登録日: 2007-03-20, 公開日: 2008-03-25, 最終更新日: 2023-08-30)

• 主引用文献: Kerr, I.D.,Lee, J.H.,Farady, C.J.,Marion, R.,Rickert, M.,Sajid, M.,Pandey, K.C.,Caffrey, C.R.,Legac, J.,Hansell, E.,McKerrow, J.H.,Craik, C.S.,Rosenthal, P.J.,Brinen, L.S.; Vinyl sulfones as antiparasitic agents and a structural basis for drug design.; J.Biol.Chem., 284:25697-25703, 2009; PubMed: 19620707; DOI: 10.1074/jbc.M109.014340

実験手法

X-RAY DIFFRACTION (1.65 Å)