2P5N

Crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase in complex with coenzyme NADPH

Summary for 2P5N

Entry DOI	10.2210/pdb2p5n/pdb
Descriptor	Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
Functional Keywords	aldo-keto reductase, hydroxysteroid dehydrogenase, binary complex, tim barrel, oxidoreductase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	2
Total formula weight	75576.35
Authors	El-Kabbani, O.,Dhagat, U. (deposition date: 2007-03-15, release date: 2007-10-09, Last modification date: 2023-10-25)
Primary citation	Dhagat, U.,Carbone, V.,Chung, R.P.,Schulze-Briese, C.,Endo, S.,Hara, A.,El-Kabbani, O. Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme. Acta Crystallogr.,Sect.F, 63:825-830, 2007 Cited by PubMed: 17909281 DOI: 10.1107/S1744309107040985 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation