2P59

Crystal Structure of Hepatitis C Virus NS3.4A protease

Summary for 2P59

Entry DOI	10.2210/pdb2p59/pdb
Descriptor	NS3, peptide, (2S,3AS,7AS)-1-[(2S)-2-{[(2S)-2-CYCLOHEXYL-2-({[(2R)-4-NITRO-2H-PYRROL-2-YL]CARBONYL}AMINO)ACETYL]AMINO}-3,3-DIMETHYLBUTANOYL]-N-{(1S)-1-[(1R)-2-(CYCLOPROPYLAMINO)-1-HYDROXY-2-OXOETHYL]BUTYL}OCTAHYDRO-1H-INDOLE-2-CARBOXAMIDE (3 entities in total)
Functional Keywords	hcv protease, viral protein
Biological source	Hepatitis C virus More
Total number of polymer chains	4
Total formula weight	43242.94
Authors	Perni, R.B.,Wei, Y. (deposition date: 2007-03-14, release date: 2008-02-05, Last modification date: 2011-07-13)
Primary citation	Perni, R.B.,Chandorkar, G.,Cottrell, K.M.,Gates, C.A.,Lin, C.,Lin, K.,Luong, Y.P.,Maxwell, J.P.,Murcko, M.A.,Pitlik, J.,Rao, G.,Schairer, W.C.,Van Drie, J.,Wei, Y. Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics. Bioorg.Med.Chem.Lett., 17:3406-3411, 2007 Cited by PubMed: 17482818 DOI: 10.1016/j.bmcl.2007.03.090 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation