2P54
a crystal structure of PPAR alpha bound with SRC1 peptide and GW735
Summary for 2P54
Entry DOI | 10.2210/pdb2p54/pdb |
Descriptor | Peroxisome proliferator-activated receptor alpha, Nuclear receptor coactivator 1, 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID, ... (4 entities in total) |
Functional Keywords | ppar alpha gw735 src1 agonist hdlc, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q07869 Nucleus (By similarity): Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 32267.71 |
Authors | Xu, R.X.,Xu, H.E.,Sierra, M.L.,Montana, V.G.,Lambert, M.H.,Pianetti, P.M. (deposition date: 2007-03-14, release date: 2007-04-24, Last modification date: 2024-04-03) |
Primary citation | Sierra, M.L.,Beneton, V.,Boullay, A.B.,Boyer, T.,Brewster, A.,Donche, F.,Forest, M.C.,Fouchet, M.H.,Gellibert, F.J.,Grillot, D.A.,Lambert, M.H.,Laroze, A.,Grumelec, C.L.,Linget, J.M.,Montana, V.G.,Nguyen, V.L.,Nicodeme, E.,Patel, V.,Penfornis, A.,Pineau, O.,Pohin, D.,Potvain, F.,Paulain, G.,Ruault, C.B.,Saunders, M.,Toum, J.,Xu, H.E.,Xu, R.X.,Pianetti, P.M. Substituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPAR Agonists. 1.Discovery of a Novel Series of Potent HDLc Raising Agents. J.Med.Chem., 50:685-695, 2007 Cited by PubMed: 17243659DOI: 10.1021/jm058056x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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